179386-44-8

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Sumanirole 马来酸盐

179386-44-8

编号ABP000216 化学名称Sumanirole 马来酸盐 英文名称 U-95666E(Sumanirole maleate)/U95666E MDL: MFCD09832637 分子式C11H13N3O.C4H4O4 分子量319.315 纯度 >99%

化学名称 : Sumanirole 马来酸盐

CAS : 179386-44-8

英文名称: U-95666E(Sumanirole maleate)/U95666E

英文同义词: SUMANIROLE MALEATE

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function. In rats, sumanirole is a full agonist for elevation of striatal acetylcholine levels (ED50 = 12.1 μmol/kg i.p.). Sumanirole s.c. dose dependently decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta with an ED50 of 2.3 μmol/kg i.v.

参考文献

[1] http://en.wikipedia.org/wiki/Sumanirole

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