化学名称 : 2-(2-氨基-3-甲氧苯基)色酮
CAS : 167869-21-8
英文名称: PD-98059/PD98059/
英文同义词: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
溶解度:Soluble to 100 mM in DMSO
储存条件:Store at +4°C
生物活性
Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
参考文献
Ahn et al (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 16 411. Ahn et al (2009) Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 4 763.