1276105-89-5
1276105-89-5
编号ABP001113
化学名称CNX1351
英文名称 CNX1351
分子式C30H35N7O3S
分子量573.709
纯度 98%
化学名称 : CNX1351
CAS : 1276105-89-5
英文名称: CNX1351
英文同义词: 5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-
同义词: 5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-
Biologieal
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant-
BI-D1870
501437-28-1
-
DHEA/Astenile/Deandros/Diandron/Diandrone/PRASTERONE/17-Chetovis/Psicosterone/17-Hormoforin/ANDROSTENOLONE
53-43-0
-
PF562271
717907-75-0
-
PD169316
152121-53-4
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