1258861-20-9

LY2940680

1258861-20-9

编号ABP000897 化学名称LY2940680 英文名称 LY2940680 分子式C26H24F4N6O 分子量512.502 纯度 98%

化学名称 : LY2940680

CAS : 1258861-20-9

英文名称: LY2940680

英文同义词: 4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

LDE225(NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 μmol/l. Topical application of a 1% LDE225(NVP-LDE225) solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution.

参考文献

[1] Stuetz A. et al. Melanoma Research. 2010 6; 20: 40

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