1239262-52-2

Tubastatin A

1239262-52-2

编号ABP000154 化学名称Tubastatin A 英文名称 Tubastatin A 分子式C20H21N3O2 分子量335.3996 纯度 >98%

化学名称 : Tubastatin A

CAS : 1239262-52-2

英文名称: Tubastatin A

英文同义词: N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide

溶解度:4 deg C

储存条件:at -20℃ 2 years

生物活性

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.1 Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).1 Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.1

参考文献

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

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