1196681-44-3

BMS-777607

1196681-44-3

编号ABP000925 化学名称BMS-777607 英文名称 BMS-777607/BMS777607/ 分子式C25H19ClF2N4O4 分子量512.893 纯度 >99%

化学名称 : BMS-777607

CAS : 1196681-44-3

英文名称: BMS-777607/BMS777607/

英文同义词: N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

PD318088(PD-318088) is a non-ATP competitive allosteric MEK1/2 inhibitor. MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway.The MEK1 inhibitor PD318088 binds simultaneously with ATP in a region of the kinase active site that is adjacent to the ATP-binding site. Birb796 binding to p38  extends into the ATP site, but also accesses this back pocket, partly overlapping the region where PD318088 binds in MEK1

参考文献

[1] Ohren JF et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.
[2] Sebolt-Leopold JS et al. Nature. 2006 May 25;441(7092):457-62.

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