1029872-54-5

PLX-4032(RG7204)/PLX4032

1029872-54-5

编号ABP000429 化学名称PLX-4032(RG7204)/PLX4032 英文名称 PLX-4032(RG7204)/PLX4032 分子式C23H18ClF2N3O3S 分子量489.922 纯度 >99%

化学名称 : PLX-4032(RG7204)/PLX4032

CAS : 1029872-54-5

英文名称: PLX-4032(RG7204)/PLX4032

英文同义词: N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and about eight percent of all solid tumors. [2]
BRAF mutant melanoma cell strains were highly sensitive to PLX4032 with IC50 in the nM range (60–450 nM), whereas BRAF wild-type cells were resistant, with IC50 2.4 μM or above. [3]

参考文献

[1] Elisa Sala1 et al. Mol Cancer Res. 2008 May; 6(5):751-9

[2] http://www.medicalnewstoday.com/articles/152309.php

[3] Ruth Halaban et al. Pigment Cell Melanoma Res. 2010 April; 23(2): 190-200

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