102676-47-1

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法倔唑

102676-47-1

编号ABP000975 化学名称法倔唑 英文名称 Fadrozole MDL: MFCD02313480 分子式C14H13N3 分子量223.2731 纯度 >98%

化学名称 : 法倔唑

CAS : 102676-47-1

英文名称: Fadrozole

英文同义词: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

溶解度:Soluble to 100 mM in DMSO and to 50 mM in ethanol

储存条件:Store at +4°C

生物活性

Selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). Selective for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming.

参考文献

Gellibert et al (2004) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors. J.Med.Chem. 47 4494. PMID: 15317461. Li et al (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4 16. PMID: 19097958.
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