化学名称 : SGX-523
CAS : 1022150-57-7
英文名称: SGX-523
英文同义词: 6-(6-(1-Methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline
溶解度:Unknown
储存条件:at -20C 2 years
生物活性
SGX-523, an orally bioavailable small molecule, specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway. This agent has shown exceptional selectivity for the cMET receptor tyrosine kinase over more than 200 protein kinases.SGX-523 may induce cell death in tumor cells expressing c-Met in vitro and in vivo.Currently, one Phase I studies are performed to evaluate the safety, tolerability and pharmacokinetic profile of SGX523.
参考文献
1. http://203.208.39.132/search?q=cache:XczNp-GS9eIJ:usstock.jrj.com.cn/2008-01-16/000003186974.shtml+SGX-523&cd=1&hl=zh-CN&ct=clnk&gl=cn&st_usg=ALhdy2_9ZP-CEhYe4S-13yHxUfNd_oXrWg