Chemical Name : ESI-09
CAS : 263707-16-0
ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells with IC50 of 1.4 uM/3.2 uM for EPAC2/EPAC1 respectively.