MK-1775/MK1775

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MK-1775/MK1775

MK-1775/MK1775

Cat.No.ABP000952 Chemical NameMK-1775/MK1775 CAS955365-80-7 MolFormulaC27H32N8O2 MolWeight500.5954 Purity >99%

Chemical Name : MK-1775/MK1775

CAS : 955365-80-7

Synonyms: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3h-pyrazolo[3,4-d]pyrimidin-3-one

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor with an IC50 of 0.058 ± 0.006 μM. It binds to the NH2-terminal ATP-binding pocket of Hsp90. Given the mechanism of action, preclinical activity profile, tolerability, and pharmaceutical properties, NVP-BEP800 is an exciting new oral Hsp90 inhibitor warranting further development. [1][2]

Reference

[1] Massey AJ et al. Mol Cancer Ther. 2010 Apr; 9(4):906-19

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