PHA-680632 /PHA680632

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PHA-680632 /PHA680632

PHA-680632 /PHA680632

Cat.No.ABP000945 Chemical NamePHA-680632 /PHA680632 CAS398493-79-3 MolFormulaC28H35N7O2 MolWeight501.6232 Purity >99%

Chemical Name : PHA-680632 /PHA680632

CAS : 398493-79-3

Synonyms: N-(2,6-二乙基苯基)-4,6-二氢-3-[[4-(4-甲基-1-哌嗪基)苯甲酰基]氨基]吡咯并[3,4-c]吡唑-5(1H)-甲酰胺


储存条件:-20C 2 years


MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the e Aurora A kinase (serine/threonine protein kinas) with potential antineoplastic activity.MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.After treatment in eight multiple myeloma cell lines with MLN8237 (0.0001 µM-4 µM) for 48 h, the affect of Aurora A kinase inhibition and a marked effect on both viability and proliferation (0.01 µM) was examined. Tumor burden was significantly reduced and overall survival was significantly increased in animals treated with 30mg/kg MLN8237.


1. Mengkun Zhang. Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models. 2009 ASCO Annual Meeting