Brivanib alaninate/BMS-582664/

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Brivanib alaninate/BMS-582664/

Brivanib alaninate/BMS-582664/

Cat.No.ABP000936 Chemical NameBrivanib alaninate/BMS-582664/ CAS649735-63-7 MDL: MFCD11983052 MolFormulaC22H24FN5O4 MolWeight441.461 Purity >99%

Chemical Name : Brivanib alaninate/BMS-582664/

CAS : 649735-63-7



Storage:at -20℃ 2 years


Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-ß and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50 = 6 nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-ß, c-KIT, and Flt3. However,sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines.


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2, Wilhelm, S., et al. "The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines." Proc. Am. Assoc. Cancer Res. 44: 106609 (2003).