PD318088/PD-318088/

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PD318088/PD-318088/

PD318088/PD-318088/

Cat.No.ABP000924 Chemical NamePD318088/PD-318088/ CAS391210-00-7 MolFormulaC16H13BrF3IN2O4 MolWeight561.089 Purity >99%

Chemical Name : PD318088/PD-318088/

CAS : 391210-00-7

Synonyms: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide

Storage:at -20℃

Biologieal

BIX-02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. [1] It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system. [2]

Reference

[1] Tatake RJ et al. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5

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