Darunavir Ethanolate(Prezista)/TMC114

溶解度:Soluble in water

储存条件:-20C 2 years

生物活性

Raltegravir targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.

参考文献

1. Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant. Garvey, E.P., Schwartz, B., et al. 2009 Biochemistry 48 (7), pp. 1644-1653