PP242 /PP-242

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PP242 /PP-242

PP242 /PP-242

Cat.No.ABP000904 Chemical NamePP242 /PP-242 CAS1092351-67-1 MDL: MFCD12196869 MolFormulaC16H16N6O MolWeight308.343 Purity ≥98% by HPLC

Chemical Name : PP242 /PP-242

CAS : 1092351-67-1

Synonyms: PP242


Storage:at -20℃ 2 years


XL765(SAR245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively. It is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). In preclinical studies, XL765 slowed tumor growth or caused tumor shrinkage in multiple preclinical cancer models, including breast, lung, ovarian, and prostate cancers, and gliomas. XL765 has also been shown to enhance the anti-tumor effects of several chemotherapeutic agents in preclinical cancer models.


[1] Garcia-Echeverria C et al. Oncogene. 2008 Sep 18;27(41):5511-26