Telatinib(BAY57-9352)/BAY57-9352

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Pelitinib inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.

参考文献

[1] http://clincancerres.aacrjournals.org/content/14/1/215.full.pdf+html