Motesanib Diphosphate/AMG-706

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Motesanib Diphosphate/AMG-706

Motesanib Diphosphate/AMG-706

Cat.No.ABP000867 Chemical NameMotesanib Diphosphate/AMG-706 CAS857876-30-3 MDL: MFCD12407403 MolFormulaC22H23N5O.2H3O4P MolWeight569.445 Purity 99%

Chemical Name : Motesanib Diphosphate/AMG-706

CAS : 857876-30-3

Synonyms: MOTESANIB DIPHOSPHATE

Solubility:Soluble in DMSO at 200 mg/ml

Storage:-20C 2 years

Biologieal

Lapatinib is a potent inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM), ErbB-4 kinase (Ki = 347 nM). Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive breast cancer models.

Reference

1��Burris, H.A. III "Dual Kinase Inhibition in the Treatment of Breast Cancer: Initial Experience with the EGFR/ErbB-2 Inhibitor Lapatinib." Oncologist 9: 10-15 (2004).

2��Wood, E.R., et al. "A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib), Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells." Cancer Res. 64: 6652-6659 (2004).

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