AT 7519 mesylate/

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AT 7519 mesylate/

AT 7519 mesylate/

Cat.No.ABP000846 Chemical NameAT 7519 mesylate/ MolFormula MolWeight0.0

Chemical Name : AT 7519 mesylate/


Solubility:Soluble in distilled water

Storage:-20C 2 years


SNS-032 (formerly BMS-387032) is a small-molecule cyclin-dependent kinase (CDK) inhibitor currently in phase I clinical trials for the treatment of B-cell malignancies and advanced solid tumors.Preclinical studies have shown that SNS-032 is a specific and potent inhibitor of CDK2, 7 and 9 which induces cell cycle arrest and apoptosis in tumor cell lines. It was shown to inhibit in vitro angiogenesis and prostaglandin E2 (PGE2) production, both strongly associated with tumorigenesis. Phase I clinical trials support the safety and tolerability of SNS-032 as evaluated in dose-escalation studies. The compound is currently administered by i.v. infusion but has shown promising potential for oral delivery.


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