Palmatine chloride /

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Palmatine chloride /

Palmatine chloride /

Cat.No.ABP000690 Chemical NamePalmatine chloride / CAS10605-02-4 MDL: MFCD00016656 MolFormulaC21H22NO4.Cl MolWeight387.861

Chemical Name : Palmatine chloride /

CAS : 10605-02-4

Synonyms: PALMATINE CHLORIDE

Biologieal

Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) is a hydrochloride salt of palmatine which is a protoberberine alkaloid. Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. [1] Palmatine inhibited carbachol-induced Ca2+-activated Cl− secretion and the carbachol-induced increase of intracellular Ca2+ concentration. Palmatine also inhibited cAMP-activated Cl− secretion induced by prostaglandin E2 (PGE2) or forskolin. Palmatine prevented the elevation of intracellular cAMP by forskolin. Determination of apical Cl− currents showed that palmatine suppressed the forskolin-stimulated, apical cAMP-activated Cl− current but not the carbachol-stimulated apical Ca2+-activated Cl− current.

Reference

[1] http://en.wikipedia.org/wiki/Palmatine

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