BAY73-4506(Regorafenib)/

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BAY73-4506(Regorafenib)/

BAY73-4506(Regorafenib)/

Cat.No.ABP000611 Chemical NameBAY73-4506(Regorafenib)/ CAS755037-03-7 MolFormulaC21H15ClF4N4O3 MolWeight482.815 Purity >99%

Chemical Name : BAY73-4506(Regorafenib)/

CAS : 755037-03-7

Synonyms: 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

Solubility:DMSO

Storage:at -20℃2years

Biologieal

BAY 73-4506 is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. BAY 73-4506 binds to and inhibits VEGFR-2 and -3, and tumor cell signaling kinases (RET, KIT, PDGFR, and Raf), which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. This drug shows potent, oral activity in a wide variety of preclinical xenograft models. [1]

Reference

[1] S. Hedbom et al. Meeting:2007 ASCO Annual Meeting.Citation:Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 25(18S):3593

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