NPS 2143 hydrochloride

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NPS 2143 hydrochloride

NPS 2143 hydrochloride

Cat.No.ABP000462 Chemical NameNPS 2143 hydrochloride CAS284035-33-2 MolFormulaC24H26Cl2N2O2 MolWeight445.381 Purity 98%

Chemical Name : NPS 2143 hydrochloride

CAS : 284035-33-2

Synonyms: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride

Solubility:Desiccate at RT

Storage:at -20℃ 2 years


Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.


Nemeth et al (2001) Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J.Pharmacol.Exp.Ther. 299 323. Nemeth (2002) The search for calcium receptor antagonists (calcilytics). J.Mol.Endocrinol. 29 15. Huang and Breitwieser (2007) Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J.Biol.Chem. 282 9517.