Chemical Name : Anacardic acid
CAS : 16611-84-0
Synonyms: 6-pentadecylsalicylic acid
Anacardic Acid is a pentadecane aliphatic chain containing hydroxylcarboxylic acid. The acid is an effective inhibitor of the activities of p300 and p300/CBP associated factor histone acetyltransferase. Additionally, it has been shown to potently inhibit HAT-dependent transcription and SUMOylation, as well as decrease expression of NF-κB regulated gene products including, invasion, proliferation, inflammation, and cell survival. Research suggests that anacardic acid may be a potent activator of ARK-1 (Aurora kinase A) mediated phosphorylation of histone H3, and a novel activator of Aurora kinase. Anacardic Acid has demonstrated bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA).
K. Balasubramanyam, et al. Small molecule modulators of histone acetyltransferase p300. J. Biol. Chem. 2003, 278, 19134. Y. Sun et al. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006, 580, 4353. B Sung et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. Blood. 2008, 111(10), 4880-91.