SB 216763/SB-216763
SB 216763/SB-216763
Cat.No.ABP000231
Chemical NameSB 216763/SB-216763
CAS280744-09-4
MolFormulaC19H12Cl2N2O2
MolWeight371.217
Purity >99%
Chemical Name : SB 216763/SB-216763
CAS : 280744-09-4
Synonyms: 3-(2,4-Dichlorophenyl)-4-(1-methyl- 1H-indol-3-yl)-1H-pyrrole-2,5-dione
Solubility:20 mg/mL in DMSO
Storage:Storage at -20C 2 years
Biologieal
Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. Also reduces pulmonary inflammation and fibrosis in a mouse model.-
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