Chemical Name : Tubastatin A
CAS : 1239262-52-2
溶解度:4 deg C
储存条件:at -20℃ 2 years
生物活性
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.1 Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).1 Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.1
参考文献
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease