Chemical Name : JNJ-38877605/JNJ38877605
CAS : 943540-75-8
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
c-Met inhibitor JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis.
参考文献
1. Liu X, Yao W, Newton RC, Scherle PA. Scherle.Targeting the c-MET signaling pathway for cancer therapy. Expert Opin Investig Drugs. 2008 Jul;17(7):997-1011