SU-11274/SU11274,PKI-SU11274

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SU-11274/SU11274,PKI-SU11274

SU-11274/SU11274,PKI-SU11274

Cat.No.ABP000133 Chemical NameSU-11274/SU11274,PKI-SU11274 CAS658084-23-2 MolFormulaC28H30ClN5O4S MolWeight568.087 Purity 97%

Chemical Name : SU-11274/SU11274,PKI-SU11274

CAS : 658084-23-2

Synonyms: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dim ethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrr ol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-i ndole-5-sulfonamide

Solubility:Soluble in DMSO 10 mg/ml at 60

Storage:Store at -20°C

Biologieal

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.
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