SGX-523

SGX-523

SGX-523

Cat.No.ABP000132 Chemical NameSGX-523 CAS1022150-57-7 MolFormulaC18H13N7S MolWeight359.408 Purity >99%

Chemical Name : SGX-523

CAS : 1022150-57-7

Synonyms: 6-(6-(1-Methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline

Storage:at -20C 2 years

Biologieal

SGX-523, an orally bioavailable small molecule, specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway. This agent has shown exceptional selectivity for the cMET receptor tyrosine kinase over more than 200 protein kinases.SGX-523 may induce cell death in tumor cells expressing c-Met in vitro and in vivo.Currently, one Phase I studies are performed to evaluate the safety, tolerability and pharmacokinetic profile of SGX523.

Reference

1. http://203.208.39.132/search?q=cache:XczNp-GS9eIJ:usstock.jrj.com.cn/2008-01-16/000003186974.shtml+SGX-523&cd=1&hl=zh-CN&ct=clnk&gl=cn&st_usg=ALhdy2_9ZP-CEhYe4S-13yHxUfNd_oXrWg

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