VX-680 (MK-0457)

VX-680 (MK-0457)

VX-680 (MK-0457)

Cat.No.ABP000120 Chemical NameVX-680 (MK-0457) CAS639089-54-6 MDL: MFCD13185152 MolFormulaC23H28N8OS MolWeight464.586 Purity 98%

Chemical Name : VX-680 (MK-0457)

CAS : 639089-54-6

Synonyms: N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-cyclopropanecarboxamide

Solubility:Soluble in DMSO

Storage:-20C 2 years


VX-680 inhibits Aurorakinases A,B and C with Ki values of 0.6, 18 and 4.6 nM, resp. It also inhibits Flt-3 and Abl as well as their mutant forms


1Giles FJ, MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.Blood. 2007 Jan 15;109(2):500-2.