Home / Products / Inhibitors / Aurora Kinase Inhibitors / AZD1152-HQPA(Barasertib)/


Cat.No.ABP000117 Chemical NameAZD1152-HQPA(Barasertib)/ CAS722544-51-6 MDL: MFCD10687152 MolFormulaC26H30FN7O3 MolWeight507.567 Purity >99%

Chemical Name : AZD1152-HQPA(Barasertib)/

CAS : 722544-51-6

Synonyms: AZD1152-HQPA


Storage:-20C 2 years


AZD1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline Aurora kinase inhibitor [AZD1152�Chydroxyquinazoline pyrazol anilide (HQPA)] and is converted rapidly to the active AZD1152-HQPA in plasma . AZD1152-HQPA is a highly potent and selective inhibitor of Aurora B (Ki, 0.36 nM) compared with Aurora A (Ki, 1,369 nM) and has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.


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