PIK-93

PIK-93

PIK-93

Cat.No.ABP000097 Chemical NamePIK-93 CAS593960-11-3 MolFormulaC14H16ClN3O4S2 MolWeight389.878 Purity >99%

Chemical Name : PIK-93

CAS : 593960-11-3

Synonyms: N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

PIK-93 is a PI4KIIIβ inhibitor (IC50 at 19 nM). PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIIIβ at low-nanomolar range. In addition, this compound also inhibits potently PI3Kγ in vitro (IC50 at 16 nM). This compound inhibits p110α, p110β, p110δwith IC50 of 0.039, 0.59, 0.12 µM. PIK-93 also displays the typical hydrogen bonding to the backbone amide of Val882, and additional ones to the backbone carbonyl of Val882 and between its sulphonamide and Asp964.

Reference

Cmiljanovic V et al. Biochim Biophys Acta. 2008 Jan; 1784(1):159-85
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