943540-75-8

JNJ-38877605/JNJ38877605

943540-75-8

Cat.No.ABP000134 Chemical NameJNJ-38877605/JNJ38877605 MolFormulaC19H13F2N7 MolWeight377.3502 Purity >98%

Chemical Name : JNJ-38877605/JNJ38877605

CAS : 943540-75-8

Synonyms: 6-[Difluoro[6-(1-methyl-1h-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

c-Met inhibitor JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis.

Reference

1. Liu X, Yao W, Newton RC, Scherle PA. Scherle.Targeting the c-MET signaling pathway for cancer therapy. Expert Opin Investig Drugs. 2008 Jul;17(7):997-1011

Enquiry