938444-93-0

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D-106669

938444-93-0

Cat.No.ABP000091 Chemical NameD-106669 MolFormulaC17H18N6O MolWeight322.3644 Purity >98%

Chemical Name : D-106669

CAS : 938444-93-0

Synonyms: 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea

Solubility:DMSO

Storage:-20c two years

Biologieal

D-106669 has been disclosed with a submicromolar inhibition of PI3Ka.Its pyridopyrazine core,substituted by an anilino residue,has been the base scaffold of a more advanced derivative AEZS-126.this molecule is described as selectitively inhibiting class I PI3K and showed some activity in A549(lung cancer)xenografts mouse model at oral dose of 30mg/kg twice daily

Reference

Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
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