929095-18-1

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GSK461364/GSK-461364

929095-18-1

Cat.No.ABP000820 Chemical NameGSK461364/GSK-461364 MolFormulaC27H28F3N5O2S MolWeight543.604 Purity >99%

Chemical Name : GSK461364/GSK-461364

CAS : 929095-18-1

Synonyms: 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide

Storage:-20℃

Biologieal

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.

Reference

[1] Morgan MA et al. Cancer Res. 2010 Jun 15;70(12):4972-81

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