648450-29-7

 Home / Products / Inhibitors / PI3K Inhibitor / 648450-29-7
AS-605240/AS605240

648450-29-7

Cat.No.ABP000101 Chemical NameAS-605240/AS605240 MolFormulaC12H7N3O2S MolWeight257.268 Purity >99%

Chemical Name : AS-605240/AS605240

CAS : 648450-29-7

Synonyms: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. This agent is the first examples of selective PI3K γ inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.

Reference

[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85

Enquiry