Chemical Name : Darunavir Ethanolate(Prezista)/TMC114
CAS : 635728-49-3
溶解度:Soluble in water
储存条件:-20C 2 years
生物活性
Raltegravir targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.
参考文献
1. Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant. Garvey, E.P., Schwartz, B., et al. 2009 Biochemistry 48 (7), pp. 1644-1653