501925-31-1

PNU120596/PNU-120596

501925-31-1

Cat.No.ABP000345 Chemical NamePNU120596/PNU-120596 MolFormulaC13H14ClN3O4 MolWeight311.721 Purity >99%

Chemical Name : PNU120596/PNU-120596

CAS : 501925-31-1

Synonyms: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea

Storage:at -20℃ 2 years

Biologieal

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration

Reference

Hurst et al (2005) A novel positive allosteric modulator of the a7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J.Neurosci. 25 4396.

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