425386-60-3

LY450139(Semagacestat) /LY-450139/Semagacestat

425386-60-3

Cat.No.ABP000262 Chemical NameLY450139(Semagacestat) /LY-450139/Semagacestat MDL: MFCD09970409 MolFormulaC19H27N3O4 MolWeight361.439

Chemical Name : LY450139(Semagacestat) /LY-450139/Semagacestat

CAS : 425386-60-3

Synonyms: SEMAGACESTAT

Biologieal

Semagacestat(LY450139) is a γ-secretase blocker with an IC50 of 15 nM.β-amyloid is a peptide of 39 to 43 amino acids. [1] The isoforms with 40 and 42 amino acids (Aβ40/42) are the main constituents of amyloid plaques in the brains of Alzheimer’s disease patients. β-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer’s. Semagacestat blocks the enzyme γ-secretase, which (along with β-secretase) is responsible for APP proteolysis. [2

Reference

[1] Kreft AF et al. J Med Chem. 2009 Oct 22;52(20):6169-88.

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