356559-20-1

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SB 525334/SB525334

356559-20-1

Cat.No.ABP000161 Chemical NameSB 525334/SB525334 MolFormulaC21H21N5 MolWeight343.4249 Purity >98%

Chemical Name : SB 525334/SB525334

CAS : 356559-20-1

Synonyms: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Solubility:DMSO

Storage:at -20°

Biologieal

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50=14.3 nM). This agent inhibits TGF-β-induced ALK5 serine/ threonine kinase activity, thereby preventing phosphorylation of the Smad transcription factors and subsequent gene activation.

Reference

[1] Laping NJ. IDrugs 1999;2:907-14

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