104987-11-3

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FK-506/Tacrolimus

104987-11-3

Cat.No.ABP000474 Chemical NameFK-506/Tacrolimus MDL: MFCD00869853 MolFormulaC44H69NO12 MolWeight804.024 Purity 99%

Chemical Name : FK-506/Tacrolimus

CAS : 104987-11-3

Synonyms: TACROLIMUS

Solubility:Soluble in DMSO at 100 mg/ml

Storage:-20C 2 years

Biologieal

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T-cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Analog (ascomycin, Cat. No. 4210) also available.
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